Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
| Molecular Profile | TP53 loss |
| Therapy | Ad5CMV-p53 gene |
| Indication/Tumor Type | colorectal cancer |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| TP53 loss | colorectal cancer | predicted - sensitive | Ad5CMV-p53 gene | Preclinical | Actionable | In a preclinical study, Ad5CMV-p53 gene therapy suppressed growth of allograft colorectal cancer in rat models (PMID: 15608394). | 15608394 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (15608394) | In vivo recombinant adenovirus-mediated p53 gene therapy in a syngeneic rat model for colorectal cancer. | Full reference... |