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Molecular Profile | FGFR3 S249C |
Therapy | Fexagratinib |
Indication/Tumor Type | urinary system cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FGFR3 S249C | urinary system cancer | sensitive | Fexagratinib | Preclinical - Cell line xenograft | Actionable | In a preclinical study, AZD4547 decreased Myc expression and inhibited growth of a urinary tract cancer cell line harboring FGFR3 S249C in culture and in xenograft models (PMID: 27401245). | 27401245 |
PubMed Id | Reference Title | Details |
---|---|---|
(27401245) | c-Myc Alteration Determines the Therapeutic Response to FGFR Inhibitors. | Full reference... |