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Molecular Profile | TP53 mutant |
Therapy | Ceralasertib + Radiotherapy |
Indication/Tumor Type | tongue squamous cell carcinoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
TP53 mutant | tongue squamous cell carcinoma | sensitive | Ceralasertib + Radiotherapy | Preclinical - Cell culture | Actionable | In a preclinical study, AZD6738 treatment increased sensitivity to radiotherapy in a tongue squamous cell carcinoma cell line harboring a TP53 mutation in culture, resulting in a greater decrease in cell survival compared to radiation treatment alone (PMID: 28062704). | 28062704 |
PubMed Id | Reference Title | Details |
---|---|---|
(28062704) | Radiosensitization by the ATR Inhibitor AZD6738 through Generation of Acentric Micronuclei. | Full reference... |