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Molecular Profile | TP53 loss |
Therapy | Ceralasertib + Radiotherapy |
Indication/Tumor Type | colorectal cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
TP53 loss | colorectal cancer | sensitive | Ceralasertib + Radiotherapy | Preclinical - Cell line xenograft | Actionable | In a preclinical study, AZD6738 increased sensitivity to radiotherapy in colorectal cancer xenograft models harboring a loss of TP53, resulting in a greater delay of tumor growth compared to radiation alone and an improved survival compared to control or either agent alone (PMID: 28062704). | 28062704 |
PubMed Id | Reference Title | Details |
---|---|---|
(28062704) | Radiosensitization by the ATR Inhibitor AZD6738 through Generation of Acentric Micronuclei. | Full reference... |