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Molecular Profile | FGFR2 amp |
Therapy | Infigratinib |
Indication/Tumor Type | colon cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FGFR2 amp | colon cancer | sensitive | Infigratinib | Preclinical - Cell culture | Actionable | In a preclinical study, Truseltiq (infigratinib) reduced Myc expression, induced cell-cycle arrest, and inhibited growth of a colon cancer cell line with FGFR2 amplification in culture (PMID: 27401245). | 27401245 |
PubMed Id | Reference Title | Details |
---|---|---|
(27401245) | c-Myc Alteration Determines the Therapeutic Response to FGFR Inhibitors. | Full reference... |