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Molecular Profile | FGFR2 amp FGFR2 over exp |
Therapy | Fexagratinib |
Indication/Tumor Type | stomach cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FGFR2 amp FGFR2 over exp | stomach cancer | sensitive | Fexagratinib | Preclinical - Pdx | Actionable | In a preclinical study, AZD4547 decreased Myc expression and inhibited tumor growth in patient-derived xenograft (PDX) models of gastric cancer with FGFR2 amplification and over expression (PMID: 27401245). | 27401245 |
PubMed Id | Reference Title | Details |
---|---|---|
(27401245) | c-Myc Alteration Determines the Therapeutic Response to FGFR Inhibitors. | Full reference... |