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| Molecular Profile | KDR over exp |
| Therapy | Sunitinib |
| Indication/Tumor Type | breast cancer |
| Response Type | predicted - resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| KDR over exp | breast cancer | predicted - resistant | Sunitinib | Preclinical | Actionable | In a preclinical study, upregulation of Kdr (Vegfr2) was identified in tumors acquired resistance to Sutent (sunitinib) in allograft models of breast cancer (PMID: 28011623). | 28011623 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (28011623) | Sunitinib Treatment Enhances Metastasis of Innately Drug-Resistant Breast Tumors. | Full reference... |