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Molecular Profile | FGFR3 L608V |
Therapy | Zoligratinib |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | decreased response |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FGFR3 L608V | Advanced Solid Tumor | decreased response | Zoligratinib | Preclinical - Cell culture | Actionable | In a preclinical study, transformed cells over expressing FGFR3 L608V demonstrated reduced sensitivity to Debio 1347 in culture (PMID: 28034880). | 28034880 |
PubMed Id | Reference Title | Details |
---|---|---|
(28034880) | Polyclonal Secondary FGFR2 Mutations Drive Acquired Resistance to FGFR Inhibition in Patients with FGFR2 Fusion-Positive Cholangiocarcinoma. | Full reference... |