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Molecular Profile | FGFR2 V564F |
Therapy | Fexagratinib |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FGFR2 V564F | Advanced Solid Tumor | resistant | Fexagratinib | Preclinical - Cell line xenograft | Actionable | In a preclinical study, transformed cells over expressing FGFR2 V564F were resistant to AZD4547 in culture and in cell line xenograft models (PMID: 25169980). | 25169980 |
PubMed Id | Reference Title | Details |
---|---|---|
(25169980) | The fibroblast growth factor receptor genetic status as a potential predictor of the sensitivity to CH5183284/Debio 1347, a novel selective FGFR inhibitor. | Full reference... |