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Molecular Profile | CDKN2A loss |
Therapy | PF-00477736 + PF3644022 |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
CDKN2A loss | Advanced Solid Tumor | predicted - sensitive | PF-00477736 + PF3644022 | Preclinical - Cell culture | Actionable | In a preclinical study, Chk1 inhibitor PF-477736 and MK2 inhibitor PF3644022 synergistically inhibited growth of multiple cancer cell lines harboring CDKN2A loss and in Cdkn2a-depleted transformed cells in culture (PMID: 26140595). | 26140595 |
PubMed Id | Reference Title | Details |
---|---|---|
(26140595) | A Synergistic Interaction between Chk1- and MK2 Inhibitors in KRAS-Mutant Cancer. | Full reference... |