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| Molecular Profile | AXL positive |
| Therapy | BMS-777607 |
| Indication/Tumor Type | glioblastoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| AXL positive | glioblastoma | sensitive | BMS-777607 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, BMS-777607 inhibited Axl phosphorylation, resulted in decreased viability of glioblastoma multiforme cell lines in culture and in cell line xenograft models (PMID: 26848524). | 26848524 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (26848524) | Inhibiting receptor tyrosine kinase AXL with small molecule inhibitor BMS-777607 reduces glioblastoma growth, migration, and invasion in vitro and in vivo. | Full reference... |