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Molecular Profile PIK3CA E545K
Therapy LY2780301
Indication/Tumor Type colon cancer
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PIK3CA E545K colon cancer predicted - sensitive LY2780301 Case Reports/Case Series Actionable In a Phase I trial, a colon cancer patient harboring PIK3CA E545K was sensitive to LY2780301, demonstrating stable disease for approximately 125 days (PMID: 25902900). 25902900
PubMed Id Reference Title Details
(25902900) A first-in-human phase I trial of LY2780301, a dual p70 S6 kinase and Akt Inhibitor, in patients with advanced or metastatic cancer. Full reference...