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Molecular Profile | TP53 loss |
Therapy | PHA-680632 + Radiotherapy |
Indication/Tumor Type | colorectal cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
TP53 loss | colorectal cancer | sensitive | PHA-680632 + Radiotherapy | Preclinical - Pdx | Actionable | In a preclinical study, PHA-680632 synergized with radiotherapy to decrease tumor growth in Pdx models deficient in Tp53 (PMID: 18026198). | 18026198 |
PubMed Id | Reference Title | Details |
---|---|---|
(18026198) | Enhancement of radiation response by inhibition of Aurora-A kinase using siRNA or a selective Aurora kinase inhibitor PHA680632 in p53-deficient cancer cells. | Full reference... |