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Molecular Profile TP53 loss
Therapy PHA-680632 + Radiotherapy
Indication/Tumor Type colorectal cancer
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
TP53 loss colorectal cancer sensitive PHA-680632 + Radiotherapy Preclinical - Pdx Actionable In a preclinical study, PHA-680632 synergized with radiotherapy to decrease tumor growth in Pdx models deficient in Tp53 (PMID: 18026198). 18026198
PubMed Id Reference Title Details
(18026198) Enhancement of radiation response by inhibition of Aurora-A kinase using siRNA or a selective Aurora kinase inhibitor PHA680632 in p53-deficient cancer cells. Full reference...