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| Molecular Profile | RET C634Y |
| Therapy | Sorafenib |
| Indication/Tumor Type | medullary thyroid carcinoma |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| RET C634Y | medullary thyroid carcinoma | predicted - sensitive | Sorafenib | Case Reports/Case Series | Actionable | In a Phase II trial, Nexavar (sorafenib) treatment resulted in stable disease in one patient with medullary thyroid carcinoma harboring RET C634Y (PMID: 20368568; NCT00390325). | 20368568 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (20368568) | Phase II clinical trial of sorafenib in metastatic medullary thyroid cancer. | Full reference... |