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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| BTK C481T | lymphoma | resistant | Ibrutinib | Preclinical - Cell culture | Actionable | In a preclinical study, lymphoma cells over expressing BTK C481T were resistant to Imbruvica (ibrutinib) in culture (PMID: 27282255). | 27282255 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (27282255) | Substitution scanning identifies a novel, catalytically active ibrutinib-resistant BTK cysteine 481 to threonine (C481T) variant. | Full reference... |