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Molecular Profile | PIK3CA C420R |
Therapy | DS-7423 |
Indication/Tumor Type | ovarian clear cell adenocarcinoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
PIK3CA C420R | ovarian clear cell adenocarcinoma | sensitive | DS-7423 | Preclinical - Cell culture | Actionable | In a preclinical study, an ovarian clear cell adenocarcinoma cell line harboring PIK3CA C420R was sensitive to DS-7423 in culture, demonstrating inhibition of cell proliferation (PMID: 24504419). | 24504419 |
PubMed Id | Reference Title | Details |
---|---|---|
(24504419) | Antitumor activity and induction of TP53-dependent apoptosis toward ovarian clear cell adenocarcinoma by the dual PI3K/mTOR inhibitor DS-7423. | Full reference... |