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| Molecular Profile | PIK3CA E545V |
| Therapy | DS-7423 |
| Indication/Tumor Type | ovarian clear cell adenocarcinoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| PIK3CA E545V | ovarian clear cell adenocarcinoma | sensitive | DS-7423 | Preclinical - Cell culture | Actionable | In a preclinical study, an ovarian clear cell adenocarcinoma cell line harboring PIK3CA E545V was sensitive to DS-7423 in culture, demonstrating inhibition of cell proliferation (PMID: 24504419). | 24504419 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (24504419) | Antitumor activity and induction of TP53-dependent apoptosis toward ovarian clear cell adenocarcinoma by the dual PI3K/mTOR inhibitor DS-7423. | Full reference... |