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Molecular Profile | APC S1197* APC S1278* |
Therapy | IWR-1 |
Indication/Tumor Type | colorectal cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
APC S1197* APC S1278* | colorectal cancer | sensitive | IWR-1 | Preclinical - Cell culture | Actionable | In a preclinical study, treatment with IWR-1 decreased active beta-catenin levels and Tcf/LEF activity, and reduced growth of a colorectal cancer cell line harboring APC S1197* and APC S1278* in culture (PMID: 28179481). | 28179481 |
PubMed Id | Reference Title | Details |
---|---|---|
(28179481) | APC Mutations as a Potential Biomarker for Sensitivity to Tankyrase Inhibitors in Colorectal Cancer. | Full reference... |