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| Molecular Profile | RET C634R RET V804M |
| Therapy | Vandetanib |
| Indication/Tumor Type | Advanced Solid Tumor |
| Response Type | resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| RET C634R RET V804M | Advanced Solid Tumor | resistant | Vandetanib | Preclinical - Cell culture | Actionable | In a preclinical study, transformed human cells co-expressing RET C634R and RET V804M were resistant to treatment with Caprelsa (vandetanib) in culture (PMID: 19029224). | 19029224 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (19029224) | Identification of tyrosine 806 as a molecular determinant of RET kinase sensitivity to ZD6474. | Full reference... |