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Molecular Profile | TP53 wild-type |
Therapy | MK-8745 |
Indication/Tumor Type | colorectal cancer |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
TP53 wild-type | colorectal cancer | predicted - sensitive | MK-8745 | Preclinical - Cell culture | Actionable | In a preclinical study, MK-8745 treatment resulted in apoptosis in Tp53 wild-type colorectal cancer cells in culture (PMID: 22293494). | 22293494 |
PubMed Id | Reference Title | Details |
---|---|---|
(22293494) | The induction of polyploidy or apoptosis by the Aurora A kinase inhibitor MK8745 is p53-dependent. | Full reference... |