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| Molecular Profile | TP53 R175L |
| Therapy | NSC319726 |
| Indication/Tumor Type | lung large cell carcinoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| TP53 R175L | lung large cell carcinoma | sensitive | NSC319726 | Preclinical - Cell culture | Actionable | In a preclinical study, lung large cell carcinoma cells harboring TP53 R175L demonstrated increased sensitivity to NSC319726 in culture (PMID: 22624712). | 22624712 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (22624712) | Allele-specific p53 mutant reactivation. | Full reference... |