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| Molecular Profile | TP53 R273W |
| Therapy | NSC319726 |
| Indication/Tumor Type | breast cancer |
| Response Type | resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| TP53 R273W | breast cancer | resistant | NSC319726 | Preclinical - Cell culture | Actionable | In a preclinical study, NSC319726 did not inhibit tumor growth in xenograft models of breast cancer harboring TP53 R273W (PMID: 22624712). | 22624712 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (22624712) | Allele-specific p53 mutant reactivation. | Full reference... |