Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
| Molecular Profile | SMARCB1 loss |
| Therapy | CFI-400945 |
| Indication/Tumor Type | atypical teratoid rhabdoid tumor |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| SMARCB1 loss | atypical teratoid rhabdoid tumor | sensitive | CFI-400945 | Preclinical - Cell culture | Actionable | In a preclinical study, CFI-400945 inhibited proliferation and decreased survival and migration of SMARCB1-deficient atypical teratoid rhabdoid tumor cells in culture (PMID: 28398638). | 28398638 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (28398638) | A functional screening of the kinome identifies the Polo-like kinase 4 as a potential therapeutic target for malignant rhabdoid tumors, and possibly, other embryonal tumors of the brain. | Full reference... |