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Molecular Profile SMARCB1 loss
Therapy CFI-400945
Indication/Tumor Type atypical teratoid rhabdoid tumor
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
SMARCB1 loss atypical teratoid rhabdoid tumor sensitive CFI-400945 Preclinical - Cell culture Actionable In a preclinical study, CFI-400945 inhibited proliferation and decreased survival and migration of SMARCB1-deficient atypical teratoid rhabdoid tumor cells in culture (PMID: 28398638). 28398638
PubMed Id Reference Title Details
(28398638) A functional screening of the kinome identifies the Polo-like kinase 4 as a potential therapeutic target for malignant rhabdoid tumors, and possibly, other embryonal tumors of the brain. Full reference...