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| Molecular Profile | NRAS G13V |
| Therapy | 3144 |
| Indication/Tumor Type | adult T-cell leukemia/lymphoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| NRAS G13V | adult T-cell leukemia/lymphoma | sensitive | 3144 | Preclinical - Pdx & cell culture | Actionable | In a preclinical study, 3144 inhibited growth of patient-derived T-cell acute lymphocytic leukemia cells harboring NRAS G13V in culture, and reduced tumor burden in xenograft models (PMID: 28235199). | 28235199 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (28235199) | Multivalent Small-Molecule Pan-RAS Inhibitors. | Full reference... |