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Molecular Profile | ATM del ATR dec exp |
Therapy | PJ34 |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | decreased response |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
ATM del ATR dec exp | Advanced Solid Tumor | decreased response | PJ34 | Preclinical - Cell culture | Actionable | In a preclinical study, ATM-null transformed cells with decreased Atr expression demonstrated decreased sensitivity to PJ34 in culture (PMID: 21840268). | 21840268 |
PubMed Id | Reference Title | Details |
---|---|---|
(21840268) | The PARP inhibitor PJ34 causes a PARP1-independent, p21 dependent mitotic arrest. | Full reference... |