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| Molecular Profile | BRAF V600E PTEN loss |
| Therapy | GSK2636771 + unspecified PD-1 antibody |
| Indication/Tumor Type | melanoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| BRAF V600E PTEN loss | melanoma | sensitive | GSK2636771 + unspecified PD-1 antibody | Preclinical | Actionable | In a preclinical study, treatment with the combination of GSK2636771 and a PD-1 antibody resulted in greater tumor infiltration of T-cells and tumor growth inhibition in mouse melanoma models expressing BRAF V600E with PTEN loss compared to either agent alone (PMID: 26645196). | 26645196 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (26645196) | Loss of PTEN Promotes Resistance to T Cell-Mediated Immunotherapy. | Full reference... |