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Molecular Profile | KIT D816V NRAS Q61R |
Therapy | Pembrolizumab + Trametinib |
Indication/Tumor Type | melanoma |
Response Type | no benefit |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
KIT D816V NRAS Q61R | melanoma | no benefit | Pembrolizumab + Trametinib | Case Reports/Case Series | Actionable | In a clinical case study, a melanoma patient harboring KIT D816V and NRAS Q61R demonstrated progressive disease when treated with a combination of Mekinist (trametinib) and Keytruda (pembrolizumab) (PMID: 28514312). | 28514312 |
PubMed Id | Reference Title | Details |
---|---|---|
(28514312) | Treatment inferred from mutations identified using massive parallel sequencing leads to clinical benefit in some heavily pretreated cancer patients. | Full reference... |