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| Molecular Profile | RET C634W |
| Therapy | RXDX-105 |
| Indication/Tumor Type | medullary thyroid carcinoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| RET C634W | medullary thyroid carcinoma | sensitive | RXDX-105 | Preclinical - Cell culture | Actionable | In a preclinical study, RXDX-105 (CEP-32496) reduced phosphorylation of RET and downstream signaling and inhibited proliferation of a medullary thyroid cancer cell line harboring RET C634W in culture (PMID: 28011461). | 28011461 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (28011461) | Antitumor Activity of RXDX-105 in Multiple Cancer Types with RET Rearrangements or Mutations. | Full reference... |