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| Molecular Profile | NTRK1 G667C NTRK1 act mut |
| Therapy | Larotrectinib |
| Indication/Tumor Type | Advanced Solid Tumor |
| Response Type | decreased response |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| NTRK1 G667C NTRK1 act mut | Advanced Solid Tumor | decreased response | Larotrectinib | Preclinical | Actionable | In a preclinical study, a cell line oncogenic mouse model expressing an NTRK1 activating mutation and a secondary resistance mutation, NTRK1 G667C, demonstrated a decrease response when treated with Vitrakvi (larotrectinib) (PMID: 28578312). | 28578312 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (28578312) | A Next-Generation TRK Kinase Inhibitor Overcomes Acquired Resistance to Prior TRK Kinase Inhibition in Patients with TRK Fusion-Positive Solid Tumors. | Full reference... |