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Molecular Profile | KMT2A fusion |
Therapy | I-BET151 + SGC0946 |
Indication/Tumor Type | acute myeloid leukemia |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
KMT2A fusion | acute myeloid leukemia | sensitive | I-BET151 + SGC0946 | Preclinical - Patient cell culture | Actionable | In a preclinical study, I-BET151 and SGC0946 synergistically inhibited proliferation of patient-derived acute myeloid leukemia cells harboring KMT2A fusions in culture (PMID: 27294782). | 27294782 |
PubMed Id | Reference Title | Details |
---|---|---|
(27294782) | Functional interdependence of BRD4 and DOT1L in MLL leukemia. | Full reference... |