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Molecular Profile | MSH6 loss |
Therapy | KU60648 |
Indication/Tumor Type | colon cancer |
Response Type | no benefit |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
MSH6 loss | colon cancer | no benefit | KU60648 | Preclinical - Cell culture | Actionable | In a preclinical study, MSH6 deficient colon cancer cells did not respond to treatment with KU60648 in culture (PMID: 28224663). | 28224663 |
PubMed Id | Reference Title | Details |
---|---|---|
(28224663) | Loss of MLH1 sensitizes colon cancer cells to DNA-PKcs inhibitor KU60648. | Full reference... |