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Molecular Profile MSH6 loss
Therapy KU60648
Indication/Tumor Type colon cancer
Response Type no benefit

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
MSH6 loss colon cancer no benefit KU60648 Preclinical - Cell culture Actionable In a preclinical study, MSH6 deficient colon cancer cells did not respond to treatment with KU60648 in culture (PMID: 28224663). 28224663
PubMed Id Reference Title Details
(28224663) Loss of MLH1 sensitizes colon cancer cells to DNA-PKcs inhibitor KU60648. Full reference...