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Molecular Profile | MSH3 loss |
Therapy | KU60648 + Radiotherapy |
Indication/Tumor Type | colon cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
MSH3 loss | colon cancer | sensitive | KU60648 + Radiotherapy | Preclinical - Cell culture | Actionable | In a preclinical study, KU60648 combined with irradiation resulted in enhanced sensitivity compared to KU60648 alone in MSH3 deficient colon cancer cells in culture, demonstrating reduced colony formation (PMID: 28224663). | 28224663 |
PubMed Id | Reference Title | Details |
---|---|---|
(28224663) | Loss of MLH1 sensitizes colon cancer cells to DNA-PKcs inhibitor KU60648. | Full reference... |