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| Molecular Profile | MSH3 loss |
| Therapy | KU60648 + Radiotherapy |
| Indication/Tumor Type | colon cancer |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| MSH3 loss | colon cancer | sensitive | KU60648 + Radiotherapy | Preclinical - Cell culture | Actionable | In a preclinical study, KU60648 combined with irradiation resulted in enhanced sensitivity compared to KU60648 alone in MSH3 deficient colon cancer cells in culture, demonstrating reduced colony formation (PMID: 28224663). | 28224663 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (28224663) | Loss of MLH1 sensitizes colon cancer cells to DNA-PKcs inhibitor KU60648. | Full reference... |