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| Molecular Profile | ALK D1091N |
| Therapy | AZD3463 |
| Indication/Tumor Type | neuroblastoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| ALK D1091N | neuroblastoma | sensitive | AZD3463 | Preclinical - Cell culture | Actionable | In a preclinical study, AZD3463 treatment in a neuroblastoma cell line harboring ALK D1091N resulted in inhibition of colony formation, repression of Pi3k signaling, and induction of apoptosis in culture (PMID: 26786851). | 26786851 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (26786851) | Novel ALK inhibitor AZD3463 inhibits neuroblastoma growth by overcoming crizotinib resistance and inducing apoptosis. | Full reference... |