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| Molecular Profile | FGFR1 amp |
| Therapy | GSK3052230 |
| Indication/Tumor Type | lung cancer |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| FGFR1 amp | lung cancer | sensitive | GSK3052230 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, GSK3052230 (FP-1039) treatment resulted in greater tumor growth inhibition (56% vs 22%) in cell line xenograft models of FGFR1 amplified lung cancer compared to FGFR1 non-amplified models (PMID: 23536011). | 23536011 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (23536011) | Blockade of nonhormonal fibroblast growth factors by FP-1039 inhibits growth of multiple types of cancer. | Full reference... |