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| Molecular Profile | BRAF D594N |
| Therapy | Vemurafenib |
| Indication/Tumor Type | Advanced Solid Tumor |
| Response Type | predicted - resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| BRAF D594N | Advanced Solid Tumor | predicted - resistant | Vemurafenib | Preclinical - Cell culture | Actionable | In a preclinical study, Zelboraf (vemurafenib) did not reduce activation of Mek in transformed cells expressing BRAF D594N in culture (PMID: 28783719). | 28783719 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (28783719) | Tumours with class 3 BRAF mutants are sensitive to the inhibition of activated RAS. | Full reference... |