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Molecular Profile | NRAS mutant |
Therapy | KO-947 |
Indication/Tumor Type | pancreatic cancer |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
NRAS mutant | pancreatic cancer | predicted - sensitive | KO-947 | Preclinical - Pdx | Actionable | In a preclinical study, KO-947 inhibited Erk signaling and induced tumor regression in patient-derived xenograft models of NRAS-mutant pancreatic cancer (Cancer Res 2017;77(13 Suppl):Abstract nr 5168). | detail... |
PubMed Id | Reference Title | Details |
---|---|---|
KO-947, a potent ERK inhibitor with robust preclinical single agent activity in MAPK pathway dysregulated tumors | Full reference... |