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Molecular Profile TP53 P98fs TP53 R175C TP53 S215G
Therapy Adavosertib + Carboplatin
Indication/Tumor Type ovarian cancer
Response Type predicted - resistant

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
TP53 P98fs TP53 R175C TP53 S215G ovarian cancer predicted - resistant Adavosertib + Carboplatin Case Reports/Case Series Actionable In a Phase II trial, Paraplatin (carboplatin) and Adavosertib (MK-1775) combination treatment resulted in disease progression in an ovarian cancer patient harboring TP53 P98fs, R175C, and S215G (PMID: 27998224; NCT01164995). 27998224
PubMed Id Reference Title Details
(27998224) Phase II Study of WEE1 Inhibitor AZD1775 Plus Carboplatin in Patients With TP53-Mutated Ovarian Cancer Refractory or Resistant to First-Line Therapy Within 3 Months. Full reference...