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Molecular Profile | RAD51D S207L |
Therapy | Talazoparib |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
RAD51D S207L | Advanced Solid Tumor | sensitive | Talazoparib | Preclinical - Cell culture | Actionable | In a preclinical study, cells expressing RAD51D S207L demonstrated decreased survival when treated with Talzenna (talazoparib) in culture (PMID: 28646019). | 28646019 |
PubMed Id | Reference Title | Details |
---|---|---|
(28646019) | Functionally Null RAD51D Missense Mutation Associates Strongly with Ovarian Carcinoma. | Full reference... |