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| Molecular Profile | JAK3 I87T |
| Therapy | JANEX-1 |
| Indication/Tumor Type | Advanced Solid Tumor |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| JAK3 I87T | Advanced Solid Tumor | sensitive | JANEX-1 | Preclinical - Cell culture | Actionable | In a preclinical study, JANEX-1 (WHI-P131) inhibited proliferation of transformed cells expressing JAK3 I87T in culture (PMID: 18397343). | 18397343 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (18397343) | Functional analysis of JAK3 mutations in transient myeloproliferative disorder and acute megakaryoblastic leukaemia accompanying Down syndrome. | Full reference... |