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Molecular Profile | KIT V560D |
Therapy | Motesanib Diphosphate |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
KIT V560D | Advanced Solid Tumor | sensitive | Motesanib Diphosphate | Preclinical - Cell culture | Actionable | In a preclinical study, Motesanib (AMG 706) inhibited KIT phosphorylation and growth of cells expressing KIT V560D in culture (PMID: 20633291). | 20633291 |
PubMed Id | Reference Title | Details |
---|---|---|
(20633291) | Motesanib inhibits Kit mutations associated with gastrointestinal stromal tumors. | Full reference... |