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Molecular Profile | PIK3CA E542K |
Therapy | Gemcitabine + LY2780301 |
Indication/Tumor Type | cervical squamous cell carcinoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
PIK3CA E542K | cervical squamous cell carcinoma | sensitive | Gemcitabine + LY2780301 | Phase Ib/II | Actionable | In a Phase Ib trial, a patient with cervical squamous cell carcinoma harboring PIK3CA E542K demonstrated a partial response when treated with a combination of LY2780301 and Gemzar (gemcitabine) (PMID: 28750271). | 28750271 |
PubMed Id | Reference Title | Details |
---|---|---|
(28750271) | Safety, tolerability and antitumour activity of LY2780301 (p70S6K/AKT inhibitor) in combination with gemcitabine in molecularly selected patients with advanced or metastatic cancer: a phase IB dose escalation study. | Full reference... |