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| Molecular Profile | KIT V560D KIT V654A |
| Therapy | Motesanib Diphosphate |
| Indication/Tumor Type | Advanced Solid Tumor |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| KIT V560D KIT V654A | Advanced Solid Tumor | sensitive | Motesanib Diphosphate | Preclinical - Cell culture | Actionable | In a preclinical study, Motesanib (AMG 706) inhibited KIT phosphorylation and growth of cells expressing a KIT V560D/V654A double mutation in culture (PMID: 20633291). | 20633291 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (20633291) | Motesanib inhibits Kit mutations associated with gastrointestinal stromal tumors. | Full reference... |