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| Molecular Profile | KIT W557_K558del KIT T670I |
| Therapy | Nilotinib |
| Indication/Tumor Type | Advanced Solid Tumor |
| Response Type | resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| KIT W557_K558del KIT T670I | Advanced Solid Tumor | resistant | Nilotinib | Preclinical - Cell culture | Actionable | In a preclinical study, transformed cells expressing a KIT W557_K558del/T670I double mutation demonstrated resistance to Tasigna (nilotinib) in culture (PMID: 17699867). | 17699867 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (17699867) | Sorafenib inhibits the imatinib-resistant KITT670I gatekeeper mutation in gastrointestinal stromal tumor. | Full reference... |