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Molecular Profile | PTEN loss |
Therapy | Idelalisib + MK2206 |
Indication/Tumor Type | diffuse large B-cell lymphoma |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
PTEN loss | diffuse large B-cell lymphoma | predicted - sensitive | Idelalisib + MK2206 | Preclinical - Cell culture | Actionable | In a preclinical study, MK2206 partially restored sensitivity to Zydelig (idelalisib) in diffuse large B-cell lymphoma cells harboring PTEN loss with acquired resistance to Zydelig (idelalisib), resulting in increased apoptosis in culture (PMID: 28178345). | 28178345 |
PubMed Id | Reference Title | Details |
---|---|---|
(28178345) | PI3Kδ inhibitor idelalisib in combination with BTK inhibitor ONO/GS-4059 in diffuse large B cell lymphoma with acquired resistance to PI3Kδ and BTK inhibitors. | Full reference... |