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Molecular Profile | KEAP1 loss NRAS Q61K |
Therapy | Trametinib |
Indication/Tumor Type | lung cancer |
Response Type | decreased response |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
KEAP1 loss NRAS Q61K | lung cancer | decreased response | Trametinib | Preclinical - Cell culture | Actionable | In a preclinical study, KEAP1 knockout resulted in decreased sensitivity to Mekinist (trametinib) in a lung cancer cell line harboring NRAS Q61K in culture (PMID: 28145866). | 28145866 |
PubMed Id | Reference Title | Details |
---|---|---|
(28145866) | KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer. | Full reference... |