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| Molecular Profile | BRAF V600E |
| Therapy | Cetuximab + PLX4720 |
| Indication/Tumor Type | colorectal cancer |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| BRAF V600E | colorectal cancer | sensitive | Cetuximab + PLX4720 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, the combination of PLX4720 and Erbitux (cetuximab) inhibited tumor growth in colorectal cancer cell line xenograft models harboring BRAF V600E (PMID: 22281684). | 22281684 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (22281684) | Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR. | Full reference... |