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Molecular Profile | BRAF V600E |
Therapy | Cetuximab + PLX4720 |
Indication/Tumor Type | colorectal cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BRAF V600E | colorectal cancer | sensitive | Cetuximab + PLX4720 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, the combination of PLX4720 and Erbitux (cetuximab) inhibited tumor growth in colorectal cancer cell line xenograft models harboring BRAF V600E (PMID: 22281684). | 22281684 |
PubMed Id | Reference Title | Details |
---|---|---|
(22281684) | Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR. | Full reference... |