Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
Molecular Profile | FBXW7 R505C |
Therapy | Regorafenib |
Indication/Tumor Type | colorectal cancer |
Response Type | resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FBXW7 R505C | colorectal cancer | resistant | Regorafenib | Preclinical - Cell culture | Actionable | In a preclinical study, colorectal cell lines with FBXW7 R505C demonstrated acquired resistance in regorafenib (PMID: 27399335). | 27399335 |
PubMed Id | Reference Title | Details |
---|---|---|
(27399335) | FBW7 mutations mediate resistance of colorectal cancer to targeted therapies by blocking Mcl-1 degradation. | Full reference... |