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| Molecular Profile | FBXW7 R505C |
| Therapy | Regorafenib |
| Indication/Tumor Type | colorectal cancer |
| Response Type | resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| FBXW7 R505C | colorectal cancer | resistant | Regorafenib | Preclinical - Cell culture | Actionable | In a preclinical study, colorectal cell lines with FBXW7 R505C demonstrated acquired resistance in regorafenib (PMID: 27399335). | 27399335 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (27399335) | FBW7 mutations mediate resistance of colorectal cancer to targeted therapies by blocking Mcl-1 degradation. | Full reference... |