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Molecular Profile | RAD51C H192_R193delinsGG RAD51C R193* RAD51C R193L RAD51C R193W |
Therapy | Rucaparib |
Indication/Tumor Type | ovarian carcinoma |
Response Type | predicted - resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
RAD51C H192_R193delinsGG RAD51C R193* RAD51C R193L RAD51C R193W | ovarian carcinoma | predicted - resistant | Rucaparib | Case Reports/Case Series | Actionable | In a clinical case study, an ovarian carcinoma patient harboring a RAD51C R193* germline mutation developed resistance to Rubraca (rucaparib) after acquisition of RAD51C R193W, RAD51C H192_R193delinsGG, and RAD51C R193L (PMID: 28588062). | 28588062 |
PubMed Id | Reference Title | Details |
---|---|---|
(28588062) | Secondary Somatic Mutations Restoring RAD51C and RAD51D Associated with Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma. | Full reference... |