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Molecular Profile | RAD51D G258Sfs*50 |
Therapy | Rucaparib |
Indication/Tumor Type | ovarian carcinoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
RAD51D G258Sfs*50 | ovarian carcinoma | sensitive | Rucaparib | Preclinical - Cell culture | Actionable | In a clinical study, an ovarian carcinoma patient harboring a RAD51D G258Sfs*50 germline mutation demonstrated stable disease when treated with Rubraca (rucaparib) (PMID: 28588062). | 28588062 |
PubMed Id | Reference Title | Details |
---|---|---|
(28588062) | Secondary Somatic Mutations Restoring RAD51C and RAD51D Associated with Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma. | Full reference... |