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Molecular Profile | FLT3 I836del |
Therapy | Midostaurin |
Indication/Tumor Type | cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FLT3 I836del | cancer | sensitive | Midostaurin | Preclinical - Cell culture | Actionable | In a preclinical study, Rydapt (midostaurin) inhibited phosphorylation of FLT3, ERK, and STAT5, and growth of transformed cells expressing FLT3 I836del in culture (PMID: 17827387). | 17827387 |
PubMed Id | Reference Title | Details |
---|---|---|
(17827387) | Uniform sensitivity of FLT3 activation loop mutants to the tyrosine kinase inhibitor midostaurin. | Full reference... |